SrasV1, Main, Exploration, bibRecord, 001283

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

Identifieur interne : 001283 ( Main/Exploration ); précédent : 001282; suivant : 001284

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

Auteurs : Jasper F. W. Chan [République populaire de Chine] ; Susanna K. P. Lau [République populaire de Chine] ; Kelvin K. W. To [République populaire de Chine] ; Vincent C. C. Cheng [République populaire de Chine] ; Patrick C. Y. Woo [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine]

Source :

Clinical Microbiology Reviews [ 0893-8512 ] ; 2015.

RBID : PMC:4402954

Descripteurs français

KwdFr :
- Animaux, Antiviraux (usage thérapeutique), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (), Infections à coronavirus (anatomopathologie), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Lutte contre l'infection, Modèles animaux de maladie humaine, Zoonoses (), Zoonoses (anatomopathologie), Zoonoses (transmission), Zoonoses (virologie), Zoonoses (épidémiologie).
MESH :
- anatomopathologie : Infections à coronavirus, Zoonoses.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- usage thérapeutique : Antiviraux, Infections à coronavirus, Zoonoses.
- virologie : Infections à coronavirus, Zoonoses.
- épidémiologie : Infections à coronavirus, Zoonoses.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Infections à coronavirus, Lutte contre l'infection, Modèles animaux de maladie humaine, Zoonoses.

English descriptors

KwdEn :
- Animals, Antiviral Agents (therapeutic use), Coronavirus Infections (epidemiology), Coronavirus Infections (pathology), Coronavirus Infections (therapy), Coronavirus Infections (transmission), Coronavirus Infections (virology), Disease Models, Animal, Humans, Infection Control, Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (physiology), Zoonoses (epidemiology), Zoonoses (pathology), Zoonoses (therapy), Zoonoses (transmission), Zoonoses (virology).
MESH :
- chemical , therapeutic use : Antiviral Agents.
- classification : Middle East Respiratory Syndrome Coronavirus.
- epidemiology : Coronavirus Infections, Zoonoses.
- pathology : Coronavirus Infections, Zoonoses.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- therapy : Coronavirus Infections, Zoonoses.
- transmission : Coronavirus Infections, Zoonoses.
- virology : Coronavirus Infections, Zoonoses.
- Animals, Disease Models, Animal, Humans, Infection Control.

Abstract

SUMMARY

The source of the severe acute respiratory syndrome (SARS) epidemic was traced to wildlife market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led to the discovery of two additional human and over 40 animal CoVs, including the prototype lineage C betacoronaviruses, Tylonycteris bat CoV HKU4 and Pipistrellus bat CoV HKU5; these are phylogenetically closely related to the Middle East respiratory syndrome (MERS) CoV, which has affected more than 1,000 patients with over 35% fatality since its emergence in 2012. All primary cases of MERS are epidemiologically linked to the Middle East. Some of these patients had contacted camels which shed virus and/or had positive serology. Most secondary cases are related to health care-associated clusters. The disease is especially severe in elderly men with comorbidities. Clinical severity may be related to MERS-CoV's ability to infect a broad range of cells with DPP4 expression, evade the host innate immune response, and induce cytokine dysregulation. Reverse transcription-PCR on respiratory and/or extrapulmonary specimens rapidly establishes diagnosis. Supportive treatment with extracorporeal membrane oxygenation and dialysis is often required in patients with organ failure. Antivirals with potent in vitro activities include neutralizing monoclonal antibodies, antiviral peptides, interferons, mycophenolic acid, and lopinavir. They should be evaluated in suitable animal models before clinical trials. Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402954

DOI: 10.1128/CMR.00102-14
PubMed: 25810418
PubMed Central: 4402954

Affiliations:

République populaire de Chine

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>SUMMARY</title>
<p>The source of the severe acute respiratory syndrome (SARS) epidemic was traced to wildlife market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led to the discovery of two additional human and over 40 animal CoVs, including the prototype lineage C betacoronaviruses, <named-content content-type="genus-species">Tylonycteris</named-content>
 bat CoV HKU4 and <named-content content-type="genus-species">Pipistrellus</named-content>
 bat CoV HKU5; these are phylogenetically closely related to the Middle East respiratory syndrome (MERS) CoV, which has affected more than 1,000 patients with over 35% fatality since its emergence in 2012. All primary cases of MERS are epidemiologically linked to the Middle East. Some of these patients had contacted camels which shed virus and/or had positive serology. Most secondary cases are related to health care-associated clusters. The disease is especially severe in elderly men with comorbidities. Clinical severity may be related to MERS-CoV's ability to infect a broad range of cells with DPP4 expression, evade the host innate immune response, and induce cytokine dysregulation. Reverse transcription-PCR on respiratory and/or extrapulmonary specimens rapidly establishes diagnosis. Supportive treatment with extracorporeal membrane oxygenation and dialysis is often required in patients with organ failure. Antivirals with potent <italic>in vitro</italic>
 activities include neutralizing monoclonal antibodies, antiviral peptides, interferons, mycophenolic acid, and lopinavir. They should be evaluated in suitable animal models before clinical trials. Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic.</p>
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<name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name>
<name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name>
<name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name>
<name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name>
<name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K. W." last="To">Kelvin K. W. To</name>
<name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K. W." last="To">Kelvin K. W. To</name>
<name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name>
<name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name>
<name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
<name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001283 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001283 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4402954
   |texte=   Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25810418" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.